Toxicity of sesquiterpene lactones.

H L, Kim

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Article . 1980

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Toxicity of sesquiterpene lactones.

descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 1980 English Journal:Research communications in chemical pathology and pharmacology, volume 28 (issn: 0034-5164,

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Authors: H L, Kim;

pmid: 7394314

Toxicity of sesquiterpene lactones.

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Abstract

The intraperitoneal LD50 of 7 sesquiterpene lactones were determined (in mg/kg): mexicanin-E (3, 3.08 +/- .10), helenalin (1, 9.86 +/- .08), hymenoxon (2, 16.24 +/- .10), psilotropin (4, 112.25 +/- .17), hymenoxon dimethyl ether (5, 141.42 +/- 0), tenulin (6, 184.65 +/- .06), and hymenolane (7, above 200). The toxicity of a sesquiterpene lactone depends on the number of alkylating centers such as cyclopentenone, alpha-methylene-gamma-lactone, or hemiacetal moieties in the molecules.

Keywords

Lethal Dose 50, Chemistry, Lactones, Mice, Chemical Phenomena, Seizures, Animals, Female, Sesquiterpenes, Anorexia

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