Phenytoin-misonidazole: possible metabolic interaction.

Following iv administration of misonidazole, evidence of decreased plasma half-life (3.8 hours versus 9.1 hours +/- 0.8 [SD] in eight other patients studied) and increased metabolism was observed in a patient receiving continuous phenytoin therapy.

Keywords

Liver, Nitroimidazoles, Phenytoin, Drug Evaluation, Humans, Drug Interactions, Infusions, Parenteral, Misonidazole, Half-Life

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