Identification of hydrazone of norethindrone, a metabolic product resulting from the interaction between isoniazid and norethindrone.

H, Watanabe; J A, Menzies; N, Jordan; J C, Loo

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Article . 1981

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Identification of hydrazone of norethindrone, a metabolic product resulting from the interaction between isoniazid and norethindrone.

descriptionPublicationkeyboard_double_arrow_right Article 25 Sep 1981 English Journal:Research communications in chemical pathology and pharmacology, volume 31 (issn: 0034-5164,

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Authors: H, Watanabe; J A, Menzies; N, Jordan; J C, Loo;

pmid: 7255877

Identification of hydrazone of norethindrone, a metabolic product resulting from the interaction between isoniazid and norethindrone.

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Abstract

Co-administration of isonicotinic acid hydrazide (isoniazid, INH) and 17 alpha-ethinyl-17 beta-hydroxyestr-4-en-3-one (norethindrone, NE) resulted in the formation of the isonicotinyl hydrazone of norethindrone (INH-NE) in rat stomach. Rat liver metabolized the latter compound in vitro. The metabolic product was characterized, following its derivatization with p-methoxy-benzaldehyde (PMBA), by comparison of chromatographic and mass spectral properties with synthetic reference compound. Results showed that INH-NE was cleaved at the amide bond resulting in the formation of the hydrazone of norethindrone. The physicochemical characteristics of synthetic PMBA hydrazone of norethindrone are described.

Keywords

Liver, Hydrazones, Isoniazid, Animals, Drug Interactions, Female, Norethindrone, Rats

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