Pharmacokinetics of bromhexine in the dog.

Bromhexine hydrochloride was administered to dogs i.v. and p.o. Plasma determinations of the unchanged drug were carried out by gas-liquid chromatography with electron-capture detection. The plasma levels obtained after i.v. administration were consistent with a two-compartment open model. Comparison of the results of i.v. and oral administration show a low bioavailability, probably due to a first pass effect.

Keywords

Bromhexine, Kinetics, Dogs, Injections, Intravenous, Administration, Oral, Animals, Biological Availability

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