Cimetidine and adrenals.

An H2-antagonist, cimetidine, reduces in the rat normal plasma corticosterone levels and strongly antagonizes their increase after cold stress. This latter effect is dose dependent. Plasma corticosterone reduction by cimetidine lasts 4 h both in normal and stress situations. Both a hypophyseal or adrenal site of action of the drug may be involved in the inhibition of adrenocortical secretion.

Country

Italy

Related Organizations

University of Chieti-Pescara
Italy

Keywords

Male, Time Factors, Physical Exertion, Guanidines, Rats, Cold Temperature, Stress, Physiological, Adrenal Glands, Animals, Cimetidine, Corticosterone

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