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Hydrophobicity and antifilarial activities of 4-aminoquinolines.

descriptionPublicationkeyboard_double_arrow_right Article 23 Jun 1983 English Journal:The Southeast Asian journal of tropical medicine and public health, volume 13 (issn: 0125-1562, Copyright policy )
Authors: M L, Go; T L, Ngiam; G, Becket; S L, Leung;

pmid: 7170648

Hydrophobicity and antifilarial activities of 4-aminoquinolines.

Abstract

The apparent partition coefficients (Papp.) of eight 4-aminoquinolines in 1-octanol/pH 7.4 buffered solutions have been determined and correlated with their reported antifilarial activities. Antifilarial activity appears to be present only in those 4-aminoquinolines which have log Papp. values falling within a narrow range of 2.8 to 3.2.

Keywords

Anthelmintics, Chemistry, Filaricides, Chemical Phenomena, Solubility, Chemistry, Physical, Aminoquinolines

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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