Authors describe two new cases of mucocutaneus lymphonode syndrome (MCLS). These are the tenth and eleventh in Italy since 1977, confirming that this syndrome, known also as Kawasaki disease, is world-wide spread. More attention is therefore required to diagnosis particularly for possible coronary artery involvement. Echocardiography may be useful in doing that. A survey of recent literature indicates that salicylate therapy may be useful not only for symptoms relief but also in preventing life threatening of coronary artery vasculitis.