Biological properties of 3-benzyl-1,2-benzisothiazole compounds.

By reaction of 3-chloro-1,2-benzisothiazole with phenylacetonitrile, 3-benzyl-1,2-benzisothiazole derivatives can be obtained. These compounds seem to mimic the benzylisoquinoline structure so they can exhibit spasmolytic activities. Both antimuscarinic and direct muscle-relaxant properties have been found with N,N-dimethyl-3-phenyl-3-(1,2-benzisothiazol-3-yl) propylamine hydrochloride.

Keywords

Thiazoles, Muscle Relaxants, Central, Guinea Pigs, Animals, Parasympatholytics, In Vitro Techniques, Acetylcholine, Histamine, Muscle Contraction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	1
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average