[Immunoglobulin FAB-fragments: specific activity and reactogenicity. III. Comparative study of the antigenic properties of anti-encephalitic gamma-globulin and FAB-fragments isolated from it].

P S, Barban; G N, Liubimova; A N, Pantiukhina; A V, Misenzhnikov

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Journal of microbiology epidemiology immunobiology

Article . 1977

Data sources: Europe PubMed Central

[Immunoglobulin FAB-fragments: specific activity and reactogenicity. III. Comparative study of the antigenic properties of anti-encephalitic gamma-globulin and FAB-fragments isolated from it].

descriptionPublicationkeyboard_double_arrow_right Article 14 Oct 1977 Russian Journal:Zhurnal mikrobiologii, epidemiologii i immunobiologii (issn: 0372-9311,

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Authors: P S, Barban; G N, Liubimova; A N, Pantiukhina; A V, Misenzhnikov;

pmid: 70912

[Immunoglobulin FAB-fragments: specific activity and reactogenicity. III. Comparative study of the antigenic properties of anti-encephalitic gamma-globulin and FAB-fragments isolated from it].

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Abstract

Parenteral administration of antiencephalytic gamma-globulin and of the Fab-fragments, extracted from it, to rabbits stimulated the formation of specific antibodies. The maximal blood serum specific antibody level in rabbits reimmunized with Fab-fragments was much lower than that following the reimmunization of rabbits with gamma-globulin. Antibodies specific to gamma-globulin and Fab-fragments were concentrated in the gamma-globulin fraction of the immune sera and could be referred to the immunoglobulins of G class.

Keywords

Hemagglutination Tests, Hemagglutination Inhibition Tests, Antibodies, Anti-Idiotypic, Immunoglobulin Fab Fragments, Antibody Specificity, Immunoglobulin G, Antibody Formation, Chromatography, Gel, Animals, Rabbits, gamma-Globulins, Antigens

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