[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].

K, Simon; K, Lapis; V V, Khudoleĭ; G B, Pliss

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Problems in oncology

Article . 1982

Data sources: Europe PubMed Central

[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].

descriptionPublicationkeyboard_double_arrow_right Article 26 Aug 1982 Russian Journal:Voprosy onkologii, volume 28 (issn: 0507-3758,

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Authors: K, Simon; K, Lapis; V V, Khudoleĭ; G B, Pliss;

pmid: 7090297

[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].

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Abstract

Tumors and precancerous lesions of the gastrointestinal tract were induced in aquarium fish guppy by dinitrosopiperazine and nitrosodiethylamine dissolved in aquarium water. Nitrosodiethylamine appeared to produce a stronger blastogenic effect than dinitrosopiperazine. Since tumors develop several weeks after exposure to carcinogens, this animal species may be used for express testing nitrosocompounds for blastogenicity.

Keywords

Male, Fish Diseases, Nitrosamines, Fishes, Animals, Diethylnitrosamine, Female, Neoplasms, Experimental, Precancerous Conditions

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