[Protective antigen of the pseudotuberculosis microbe].

M F, Dzadzieva; N N, Besednova; L A, Snishchenko; G P, Somov

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Журнал микробиологии, эпидемиологии и иммунобиологии

Article . 1981

Data sources: Europe PubMed Central

[Protective antigen of the pseudotuberculosis microbe].

descriptionPublicationkeyboard_double_arrow_right Article 24 Nov 1981 Russian Journal:Zhurnal mikrobiologii, epidemiologii i immunobiologii (issn: 0372-9311,

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Authors: M F, Dzadzieva; N N, Besednova; L A, Snishchenko; G P, Somov;

pmid: 7025531

[Protective antigen of the pseudotuberculosis microbe].

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Abstract

Proteinolipopolysaccharide (PLPS) isolated from the causative agent of pseudotuberculosis has the properties of a protective antigen. It protects 86-90% of mice and guinea-pigs from lethal Y. pseudotuberculosis infection (20 lethal doses) and stimulates humoral and cellular immunity factors, as well as the phagocytic activity of monocytes. It is of particular importance due to the fact that in Y. pseudotuberculosis infection the system of mononuclear phagocytes plays a significant role in eliminating the causative agent from the body. The further study of PLPS with the aim of developing prophylactic preparations shows good promise.

Keywords

Lipopolysaccharides, Antigens, Bacterial, Mice, Inbred NZB, Yersinia Infections, Guinea Pigs, Vaccination, Yersinia pseudotuberculosis Infections, Yersinia, Mice, Inbred C57BL, Mice, Bacterial Proteins, Mice, Inbred CBA, Animals, Hybridization, Genetic

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