The sensitivity of saprophytic and parasitic phase of some strains of Emmonsia crescens, E. parva and Chrysosporium pannorum to 22 antimycotic drugs was studied in vitro. Pyrithione produced the best effect on both live phases of the studied strains. The efficacy of Pyrithione, Pimafucin and Amphotericin B was compared in experimental adiaspiromycosis, Pyrithione showed also in vivo the best therapeutic effect. It depended on the beginning of the application. The illness did not develop if Pyrithione was applied during the first 15 days after the infection. In case of later application of Pyrithione only a very light form of adiaspiromycosis developed. Pimafucin and especially Amphotericin B did not influence the development of the disease.