[Electrocardiographic changes induced by various analogs of radicinin].
Copyright policy )[Electrocardiographic changes induced by various analogs of radicinin].
The action of some radicinin analogues has been studied on the ECG in the rat. The most active compound is 2,3-dihydro-2, 7-dimethyl-4H,5H-pyrano [4,3-b]pyran-4,5-dione (II) which induced a significant increase of the heart rate (HR) and an evident prolongation of the PR interval, especially at the highest dose. A slight but lasting increase in HR is caused by compound (VII),3-hexanoyl-4-hydroxy-6-methyl-2H-pyran-2-one, while the compound (III), 7,8-dihydro-2,7-dimethyl-4H,5H-pyrano-[4,3-b]pyran-4,5-dione caused a small prolongation of the PR time. No significant modifications are caused by the other five compounds tested.
Male, Electrocardiography, Time Factors, Heart Rate, Pyrones, Animals, Rats, Inbred Strains, Pyrans, Rats
Male, Electrocardiography, Time Factors, Heart Rate, Pyrones, Animals, Rats, Inbred Strains, Pyrans, Rats
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