The scheme of management of cervical intra-epithelial neoplasia presently utilized in the colposcopy service at Groote Schuur Hospital, Cape Town, is outlined, and the results of the treatment of 721 patients with the various modalities currently available are analysed. It is concluded that a radical approach (total hysterectomy was performed in 42,4% of the patients) is justified by the results obtained; the place of conservative methods of treatment, including cone biopsy, is discussed.