A case of disseminated superficial actinic porokeratosis (DSAP) is described in a 54 yr old woman who had renal transplantation. The disease had its onset at the time of hemodialysis treatment and became worse immediately after renal transplantation. The authors discuss the role of immunosuppressive therapy in the evolution of DSAP and the possible correlations between this dertmatosis and the actinic premalignant lesions. The authors accept that the immunosupressive therapy has a role in the recrudescence of the disease, but do not believe that porokeratosis causes an increased risk of squamous carcinoma in our patient.