Analgesic activities of amphetamine isomers.

D R, Tocco; R P, Maickel

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Article . 1984

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Analgesic activities of amphetamine isomers.

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 1984 English Journal:Archives internationales de pharmacodynamie et de therapie, volume 268 (issn: 0003-9780,

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Authors: D R, Tocco; R P, Maickel;

pmid: 6732359

Analgesic activities of amphetamine isomers.

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Abstract

The analgesic activity of single doses of d- and l-amphetamine was tested in mice using four systems: 65 degrees C hot plate, 55 degrees C hot plate, tail flick, and acetic acid-induced writhing. Although both isomers had some activity, the l-isomer was generally more potent and had a greater duration of activity.

Keywords

Male, Analgesics, Dextroamphetamine, Time Factors, Dose-Response Relationship, Drug, Stereoisomerism, Motor Activity, Amphetamine, Mice, Reaction Time, Animals

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