Healing of the external defects by the primary tension, under the scab, or by the secondary tension through the suppuration as well as the formation of granulation tissue (GT) in other organs, represent an adequate homeostatic response to the injury with stereotype kinetics of the inflammation and regeneration. The altered general and local responsiveness trophic disorders, burn and radiation trauma result in collapse of the autoregulatory mechanisms, pronounced disturbance of phagocytosis, microcirculation, mediator and contact cell interaction. This provokes the inhibition of fibroblast proliferation, depression and perversion of fibrillogenesis and the granulation tissue maturation, the formation of abnormal granulation tissue with repeated wakes of sclerosis, necrosis and inflammation, formation of persisting wounds, ulcers, hypergranulations or chronic inflammatory processes. Homeostatic protective response transforms into the pathologic response due to dissociation between the inflammation and regeneration and formation of "vicious circle".