Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.

Y, Ohba; Y, Hasegawa; H, Amino; S, Miwa; T, Nakatsuji; Y, Hattori; T, Miyaji

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Hemoglobin

Article . 1983

Data sources: Europe PubMed Central

Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.

descriptionPublicationkeyboard_double_arrow_right Article 17 Jun 1983 English Journal:Hemoglobin, volume 7 (issn: 0363-0269,

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Authors: Y, Ohba; Y, Hasegawa; H, Amino; S, Miwa; T, Nakatsuji; Y, Hattori; T, Miyaji;

pmid: 6687721

Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.

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Abstract

An electrophoretically silent unstable hemoglobin was found in a 23-year-old Japanese woman suffering from hemolytic anemia and jaundice. The unstable beta subunit was precipitated with p-chloromercuribenzoic acid and the globin was further purified by urea CM-52 column chromatography. Results of amino acid analysis, tryptic fingerprinting and manual Edman degradation of the abnormal beta T12B established a substitution of proline for histidine beta 117 (G19). This new abnormal hemoglobin was absent in other members of the family.

Keywords

Adult, Anemia, Hemolytic, Hemoglobins, Abnormal, Humans, Female, Amino Acid Sequence, Amino Acids, Globins

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