[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].
Copyright policy )[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].
A study was made of the action of the adrenocorticolytic drug chloditane (o.p'-DDD) on the content of cytochrome P-450 adrenodoxine and free radicals in the dog adrenal cortex. After a single feeding of 50 mg/kg bw o.p'-DDD EPR signals with xi-factors 2.25, 1.94 and 2.00 reduced 30-40%. Three-fold feeding of the drug in a dose of 100 mg/kg bw produced a further demonstrable decrease of signals. These changes attest to a possible inhibition of the hydroxylase complex in the adrenal cortex induced by o.p'-DDD.
Male, Dogs, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Free Radicals, Adrenodoxin, Adrenal Cortex, Animals, Cytochrome P-450 Enzyme Inhibitors, Mitotane
Male, Dogs, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Free Radicals, Adrenodoxin, Adrenal Cortex, Animals, Cytochrome P-450 Enzyme Inhibitors, Mitotane
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