[Effect of aggregating agents on the pentosephosphate pathway of carbohydrate metabolism in human blood platelet extracts].

S A, Makarov; G V, Kudriavtseva; A I, Kolotilova

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Article . 1983

Data sources: Europe PubMed Central

[Effect of aggregating agents on the pentosephosphate pathway of carbohydrate metabolism in human blood platelet extracts].

descriptionPublicationkeyboard_double_arrow_right Article 17 Dec 1983 Russian Journal:Farmakologiia i toksikologiia, volume 46 (issn: 0014-8318,

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Authors: S A, Makarov; G V, Kudriavtseva; A I, Kolotilova;

pmid: 6628659

[Effect of aggregating agents on the pentosephosphate pathway of carbohydrate metabolism in human blood platelet extracts].

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Abstract

Thrombin inhibits the rate of glucose-6-phosphate and 6-phosphogluconate oxidation. ADP decreases the incorporation of ribose-5-phosphate into metabolism. The effect of adrenaline on the pentose phosphate pathway reactions was not demonstrated. Cell destruction by means of freezing, thawing and treatment with Triton X-100 decreases the rate of the glucose-6-phosphate dehydrogenase reaction to a greater degree as compared with osmotic shock.

Keywords

Blood Platelets, Epinephrine, Octoxynol, Phosphogluconate Dehydrogenase, Fructosephosphates, Thrombin, Glucosephosphate Dehydrogenase, Polyethylene Glycols, Adenosine Diphosphate, Glucose, Osmotic Pressure, Freezing, Humans, Sugar Phosphates, Ribosemonophosphates

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