[Enzymes are the allergenic components of inhaled pancreatin].
Copyright policy )[Enzymes are the allergenic components of inhaled pancreatin].
Pancreatic extracts had caused respiratory disease in five patients. Four of them were not atopic. In four cases alpha-amylase and in two cases trypsin could be identified as causative allergen using RAST and RAST-inhibition. In addition, demonstration of immunologic cross-reactivity between porcine and bovine pancreatin was possible. This most likely can be attributed to the structurally closely related enzymes alpha-amylase and trypsin occurring in both animal species.
Adult, Male, Drug Industry, Allergens, Immunoglobulin E, Middle Aged, Bronchial Provocation Tests, Occupational Diseases, Radioallergosorbent Test, Pancreatin, Respiratory Hypersensitivity, Humans, Female, Trypsin, alpha-Amylases
Adult, Male, Drug Industry, Allergens, Immunoglobulin E, Middle Aged, Bronchial Provocation Tests, Occupational Diseases, Radioallergosorbent Test, Pancreatin, Respiratory Hypersensitivity, Humans, Female, Trypsin, alpha-Amylases
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