Linkage analysis in dominant optic atrophy.
Copyright policy )Linkage analysis in dominant optic atrophy.
A kindred of German descent was studied for dominant optic atrophy, type Kjer (McKusick catalog no. 16540). One hundred twenty-three family members were examined clinically, and 36 affected, 81 normal, and six uncertain members were ascertained. Twenty-seven markers were analyzed for 121 members. The maximum lod score obtained was 2.0 at theta = .18 for linkage between the Kidd locus and dominant optic atrophy. Twenty-eight offspring were informative with 2-generation data. There was insufficient information for the acid phosphatase locus to aid gene localization. These data suggest that the locus for dominant optic atrophy is on chromosome 2.
Genetic Markers, Male, Recombination, Genetic, Models, Genetic, Genetic Linkage, Chromosomes, Human, 1-3, Chromosome Mapping, Pedigree, Optic Atrophy, Humans, Female, Kidd Blood-Group System, Lod Score, Genes, Dominant
Genetic Markers, Male, Recombination, Genetic, Models, Genetic, Genetic Linkage, Chromosomes, Human, 1-3, Chromosome Mapping, Pedigree, Optic Atrophy, Humans, Female, Kidd Blood-Group System, Lod Score, Genes, Dominant
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