Pharmacokinetics of vinpocetine (Cavinton) in dog.

M, Polgár; L, Vereczkey

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Article . 1985

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Pharmacokinetics of vinpocetine (Cavinton) in dog.

descriptionPublicationkeyboard_double_arrow_right Article 26 Mar 1985 English Journal:Polish journal of pharmacology and pharmacy, volume 36 (issn: 0301-0244,

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Authors: M, Polgár; L, Vereczkey;

pmid: 6527972

Pharmacokinetics of vinpocetine (Cavinton) in dog.

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Abstract

The pharmacokinetics of vinpocetine after 10 mg po and iv doses was studied in six beagle dogs treated in cross-over design. The concentration of the drug in plasma was determined by gas-liquid chromatography using N-P FID and capillary column. The elimination half-live and clearance values calculated from time plasma concentration data for iv administration were 8.9 +/- 2.87 h and 4.2 +/- 1.06 1/kg/h, respectively. The bioavailability of the drug was found to be 21.5 +/- 19.3%.

Keywords

Male, Vasodilator Agents, Administration, Oral, Kinetics, Dogs, Injections, Intravenous, Animals, Female, Vinca Alkaloids, Half-Life

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