Photon activation therapy.
Copyright policy )Photon activation therapy.
It is suggested here that significant advantages should accrue from the use of 40 keV photons from implanted sources of 145Sm. These energies should stimulate Auger electron cascades from IdUrd, as well as produce non-repairable damage from radiosensitization. The use of low dose rates (approximately 10 rd/hr) should allow repair in normal tissues exposed to the activating photons. Utilization of this technique with brain tumors should minimize problems associated with radiosensitization of normal tissues, as CNS tissues do not synthesize DNA. The deposition of high LET radiations selectively in tumor cells provides unique advantages not available to either conventional therapy or other forms of particle therapy (fast neutrons, protons, pions, heavy ions).
- University of North Texas United States
Central Nervous System, Radiation-Sensitizing Agents, Antimetabolites, Rbe, Diseases, Even-Odd Nuclei, Nervous System, Hydroxy Compounds, Mice, Isotopes, Heterocyclic Compounds, Chronic Exposure, Nucleic Acids, Cricetinae, Neoplasms, Intermediate Mass Nuclei, Organic Iodine Compounds, Radiation, Organic Compounds, Electromagnetic Radiation, Drugs, Nucleosides, Combined Modality Therapy, X-Ray Sources, Rare Earth Nuclei, External Irradiation, Body, 62 Radiology And Nuclear Medicine, Local Irradiation, Odd-Even Nuclei, Patients, Radiosensitivity Effects, Beta Decay Radioisotopes, 610, Electrons, Years Living Radioisotopes 550603* -- Medicine-- External Radiation In Therapy-- (1980-), Internal Conversion Radioisotopes, Idoxuridine, Animals, Humans, Electron Capture Radioisotopes, Azines, Radioisotopes, Rare Earth Isotopes, Samarium, Ribosides, Radiotherapy, Radiation Sources, Samarium Isotopes, Labelled Compounds, Nuclei, Iodine 127, Organic Nitrogen Compounds, Organs, Low Dose Irradiation, 550604 -- Medicine-- Unsealed Radionuclides In Therapy-- (1980-), Irradiation, Therapy, Head, Neck, Thymidine, Ionizing Radiations
Central Nervous System, Radiation-Sensitizing Agents, Antimetabolites, Rbe, Diseases, Even-Odd Nuclei, Nervous System, Hydroxy Compounds, Mice, Isotopes, Heterocyclic Compounds, Chronic Exposure, Nucleic Acids, Cricetinae, Neoplasms, Intermediate Mass Nuclei, Organic Iodine Compounds, Radiation, Organic Compounds, Electromagnetic Radiation, Drugs, Nucleosides, Combined Modality Therapy, X-Ray Sources, Rare Earth Nuclei, External Irradiation, Body, 62 Radiology And Nuclear Medicine, Local Irradiation, Odd-Even Nuclei, Patients, Radiosensitivity Effects, Beta Decay Radioisotopes, 610, Electrons, Years Living Radioisotopes 550603* -- Medicine-- External Radiation In Therapy-- (1980-), Internal Conversion Radioisotopes, Idoxuridine, Animals, Humans, Electron Capture Radioisotopes, Azines, Radioisotopes, Rare Earth Isotopes, Samarium, Ribosides, Radiotherapy, Radiation Sources, Samarium Isotopes, Labelled Compounds, Nuclei, Iodine 127, Organic Nitrogen Compounds, Organs, Low Dose Irradiation, 550604 -- Medicine-- Unsealed Radionuclides In Therapy-- (1980-), Irradiation, Therapy, Head, Neck, Thymidine, Ionizing Radiations
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