beta-Cyclodextrin as an aid to peritoneal dialysis. Renal toxicity of beta-cyclodextrin in the rat.

J H, Perrin; F P, Field; D A, Hansen; R A, Mufson; G, Torosian

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Article . 1978

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beta-Cyclodextrin as an aid to peritoneal dialysis. Renal toxicity of beta-cyclodextrin in the rat.

descriptionPublicationkeyboard_double_arrow_right Article 12 Jun 1978 English Journal:Research communications in chemical pathology and pharmacology, volume 19 (issn: 0034-5164,

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Authors: J H, Perrin; F P, Field; D A, Hansen; R A, Mufson; G, Torosian;

pmid: 644130

beta-Cyclodextrin as an aid to peritoneal dialysis. Renal toxicity of beta-cyclodextrin in the rat.

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Abstract

A peritoneal dialysate containing beta-cyclodextrin has been shown to accelerate the removal of intravenously administered phenobarbital in rats. It was found that high concentrations of beta-cyclodextrin were toxic to the animals in the single exchange technique employed. The renal toxicity was estimated by measuring blood urea nitrogen values in the rats following oral and intraperitoneal administration of the cyclic amylose.

Keywords

Time Factors, Phenobarbital, Animals, Kidney Diseases, Amylose, Peritoneal Dialysis, Blood Urea Nitrogen, Rats

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