HLA phenotype and insulin antibody production.
Copyright policy )HLA phenotype and insulin antibody production.
HLA phenotypes have been determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity.
- University of Groningen Netherlands
Adult, Male, Adolescent, Insulin Antibodies, Genes, MHC Class II, HLA-DR7 Antigen, Histocompatibility Antigens Class II, Middle Aged, HLA-DR3 Antigen, Phenotype, Immunoglobulin G, Hemocyanins, HLA-DR4 Antigen, Humans, Female, Prospective Studies, Aged
Adult, Male, Adolescent, Insulin Antibodies, Genes, MHC Class II, HLA-DR7 Antigen, Histocompatibility Antigens Class II, Middle Aged, HLA-DR3 Antigen, Phenotype, Immunoglobulin G, Hemocyanins, HLA-DR4 Antigen, Humans, Female, Prospective Studies, Aged
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