Klebsiella plasmid K21 is not involved in the aetiology of ankylosing spondylitis.

K Y, Ngo; D, Rochu; A M, D'Ambrosio; J Y, Muller; G, Lucotte

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Experimental and Cli...arrow_drop_down

Experimental and Clinical Immunogenetics

Article . 1990

Data sources: Europe PubMed Central

Klebsiella plasmid K21 is not involved in the aetiology of ankylosing spondylitis.

descriptionPublicationkeyboard_double_arrow_right Article 11 Jun 1990 English Journal:Experimental and clinical immunogenetics, volume 1 (issn: 0254-9670,

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Authors: K Y, Ngo; D, Rochu; A M, D'Ambrosio; J Y, Muller; G, Lucotte;

pmid: 6401143

Klebsiella plasmid K21 is not involved in the aetiology of ankylosing spondylitis.

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Abstract

The possibility that a plasmid carried by Klebsiella pneumoniae plays a role in the pathogenesis of ankylosing spondylitis was explored. K. pneumoniae K21 contains a congruent to 25-kb plasmid, but this plasmid is not present in lymphocyte DNAs of ankylosing spondylitis HLA-B27 patients, as demonstrated by molecular hybridization experiments.

Keywords

Male, DNA, Cross Reactions, Pedigree, Blotting, Southern, Klebsiella pneumoniae, Genes, Bacterial, Humans, Female, Spondylitis, Ankylosing, Disease Susceptibility, Lymphocytes, HLA-B27 Antigen, Plasmids

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