We report a case of reticulate pigmented anomaly of the flexures in a 54 years-old white male patient. His lesions had developed during the last 30 years, involving neck, axillae, groins, anterior chest wall, scrotum, buttocks and thighs. The abnormality is characterized by pigmented epidermal downgrowths, with similar lesions developing around dilated pilosebaceous follicles. The condition may be compared with acanthosis nigricans. For this reason it is important to recognize this new genodermatosis in order to avoid unnecessary investigations to exclude visceral malignancy.