Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.
Copyright policy )Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.
Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
Male, Dextroamphetamine, Reserpine, Chemical Phenomena, Rats, Inbred Strains, Motor Activity, Piperazines, Tryptamines, Rats, 5-Hydroxytryptophan, Lethal Dose 50, Chemistry, Mice, Indenes, Seizures, Indans, Reflex, Animals, Serotonin Antagonists
Male, Dextroamphetamine, Reserpine, Chemical Phenomena, Rats, Inbred Strains, Motor Activity, Piperazines, Tryptamines, Rats, 5-Hydroxytryptophan, Lethal Dose 50, Chemistry, Mice, Indenes, Seizures, Indans, Reflex, Animals, Serotonin Antagonists
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