Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-5. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in rats.

M, Yokota; U, Takeda; M, Odaki; H, Sasaki; H, Kawaoto; H, Watanabe; N, Ishiwatari; T, Koeda

Found an issue? Give us feedback

https://pubmed.ncbi....arrow_drop_down

https://pubmed.ncbi.nlm.nih.go...

Article . 1985

Data sources: Europe PubMed Central

Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-5. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in rats.

descriptionPublicationkeyboard_double_arrow_right Article 24 Jan 1985 English Journal:The Japanese journal of antibiotics, volume 37 (issn: 0368-2781,

Copyright policy )

Authors: M, Yokota; U, Takeda; M, Odaki; H, Sasaki; H, Kawaoto; H, Watanabe; N, Ishiwatari; +1 Authors

pmid: 6334175

Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-5. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in rats.

- Summary
- Subjects
- Metrics

Abstract

Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites. At previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female rats. The object of this study was to evaluate acute toxicity in male and female rats after single oral administration of Mb2, a metabolite of MOM. It is concluded that LD0 values of Mb2 were estimated more than 5,000 mg/kg.

Keywords

Lethal Dose 50, Male, Animals, Female, Rats, Inbred Strains, Miocamycin, Leucomycins, Anti-Bacterial Agents, Rats

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average