The electric potential at the entrance of the amphotericin channel was varied by changing the membrane surface charge, modifying the charged groups of amphotericin molecule or adding of MgSO4. It has been shown that the zero current potential and channel selectivity depend on the potential at the entrance of the channel. It has been found that anion and cation current through amphotericin channel are coupled. Possible usage of CMF for studying radical stages in catalytic Fe2+-oxidation of liposomes heterogeneous processes has been shown.