An analysis of the rates of morbidity and mortality from malignant disease in Astrakhan Region showed that these indexes tend to decrease. These standardised indexes for males are higher than for females. Neoplasms tend to occur in advanced age groups, particularly, in females. The morbidity and mortality rates in the city of Astrakhan are higher than in the region. Mortality from malignant tumors ranks second after mortality from cardio-vascular diseases and is responsible for 18.3% of all causes of deaths. Within the last few years, lung cancer has been invariably the main factor claiming the lives of males.