Surface antigens of murine hemopoietic stem cells. IV. Characteristics of antisera exhibiting cell-lineage specificity, and differentiating ability of stem cells surviving treatment with antisera against cell-lineage antigens.
Copyright policy Surface antigens of murine hemopoietic stem cells. IV. Characteristics of antisera exhibiting cell-lineage specificity, and differentiating ability of stem cells surviving treatment with antisera against cell-lineage antigens.
Hemopoietic stem cells express cell-lineage antigens in common with platelets, thymocytes and macrophages. Further evidence for the cell-lineage antigen model is presented. Erythrocyte-absorbed antiserum against purified mouse neutrophils cross-reacts with the hemopoietic stem cell in a lineage-specific manner. Thus, most of the anti-stem cell activity is absorbed out with neutrophils but not by other non-granulocytic hemopoietic cells. Of the four antisera tested for anti-stem cell activity, antiplatelet serum showed the highest degree of cell-lineage specificity (96% of the anti-stem cell activity satisfied cell-lineage criteria). To test predictions of the cell-lineage model of hemopoietic cell differentiation concerning the differentiating potential of stem cells selected for low concentration of cell-lineage antigen, bone marrow cells were treated with antiplatelet serum at a predetermined concentration required to produce 75-85% loss of spleen colonies. Stem cells surviving this treatment showed normal ability to form megakaryocytes and platelets. The results are consistent with postulates of the cell-lineage model.
Blood Platelets, Neutrophils, Immune Sera, Macrophages, T-Lymphocytes, Bone Marrow Cells, Cell Differentiation, Hematopoietic Stem Cells, Models, Biological, Mice, Inbred C57BL, Epitopes, Mice, Antigens, Surface, Mice, Inbred CBA, Animals, Spleen
Blood Platelets, Neutrophils, Immune Sera, Macrophages, T-Lymphocytes, Bone Marrow Cells, Cell Differentiation, Hematopoietic Stem Cells, Models, Biological, Mice, Inbred C57BL, Epitopes, Mice, Antigens, Surface, Mice, Inbred CBA, Animals, Spleen
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