HLA-D/DR restriction of proliferative T cell responses to antigen. Enrichment of antigen-specific T cell blasts and evidence of preferential HLA-D/DR restriction.
Copyright policy )HLA-D/DR restriction of proliferative T cell responses to antigen. Enrichment of antigen-specific T cell blasts and evidence of preferential HLA-D/DR restriction.
Antigen-specific T cell blasts may be separated from alloreactive cells on Percoll gradients. The absence of alloreactivity allowed us to study HLA-D/DR restriction of proliferative T cell responses towards PPD and HSV antigens using allogeneic antigen-presenting cells. An overriding impact of self HLA-D/DR determinants as restriction elements for in vivo sensitized T cells was demonstrated. Furthermore, evidence was obtained that the proliferative PPD response might be preferentially restricted by HLA-D/DR 1.
T-Lymphocytes, Genes, MHC Class II, Cell Separation, HLA-DR Antigens, Lymphocyte Activation, Tuberculin, Epitopes, Humans, Interleukin-2, Simplexvirus, Antigens, Antigens, Viral
T-Lymphocytes, Genes, MHC Class II, Cell Separation, HLA-DR Antigens, Lymphocyte Activation, Tuberculin, Epitopes, Humans, Interleukin-2, Simplexvirus, Antigens, Antigens, Viral
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