Antacids should not be combined with other anti-ulcer drugs such as carbenoxolone, metoclopramide, domperidone, sulpiride, di-citrato-bis-muthate and alginic acid. The effect of each single drug can be negatively influenced by combined application. H2-receptor-antagonists and sucralfate seem to be useful in combination with antacids. There is no evidence up to now that goals of therapy can be attained more effectively and in a shorter time than with either a drug alone. Before pirenzepine will be given in combination with antacids, bioavailability of the drug should be proved during antacid treatment. Today antacids in combination with other antiulcer drugs cannot be recommended for routine ulcer therapy.