Inhibition of arachidonic acid 5-lipoxygenase of human polymorphonuclear leukocytes by esculetin.
Copyright policy )Inhibition of arachidonic acid 5-lipoxygenase of human polymorphonuclear leukocytes by esculetin.
Esculetin (6,7-dihydroxycoumarin) inhibits arachidonic acid 5-lipoxygenase of human polymorphonuclear leukocytes (HPMNL). Complete inhibition of the biosynthesis of 5-HETE, 5,12-DHETE and LTB4 was observed at a concentration of 100 microM (IC50 = = 0.4 microM, 6.0 microM and 0.1 microM, respectively). At these concentrations the formation of the cyclooxygenase product, 12-HHT, is increased. Upon stimulation of the cells with calcium ionophore A-23187, the inhibitory action of esculetin is revealed at the higher concentrations.
Neutrophils, Humans, Arachidonic Acids, Lipoxygenase Inhibitors, Umbelliferones, In Vitro Techniques, Leukotriene B4, Chromatography, High Pressure Liquid
Neutrophils, Humans, Arachidonic Acids, Lipoxygenase Inhibitors, Umbelliferones, In Vitro Techniques, Leukotriene B4, Chromatography, High Pressure Liquid
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