[Antitumor action of new 2,4-diethyleneimino-6-amino-sym.-triazina derivatives].

L L, Maliugina; R I, Pol'kina; B O, Kraĭz; A L, Remizov

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Problems in oncology

Article . 1978

Data sources: Europe PubMed Central

[Antitumor action of new 2,4-diethyleneimino-6-amino-sym.-triazina derivatives].

descriptionPublicationkeyboard_double_arrow_right Article 10 Mar 1978 Russian Journal:Voprosy onkologii, volume 23 (issn: 0507-3758,

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Authors: L L, Maliugina; R I, Pol'kina; B O, Kraĭz; A L, Remizov;

pmid: 602082

[Antitumor action of new 2,4-diethyleneimino-6-amino-sym.-triazina derivatives].

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Abstract

In experiments of mice and rats with transplantable tumors (sarcoma 37, sarcoma 45, ascites Ehrlich tumor, etc) the authors studied the antitumor activity of a number of new water-soluble derivatives of 2,4-diethylenimino-6-amino-sym.-triazine differing only in the substituting radical associated with sym.-triazine cycle. All substances under study showed marked antitumor activity. The effect of the structure of the compounds concerned and their physico-chemical properties for antitumor activity are discussed.

Keywords

Blood Cells, Time Factors, Dose-Response Relationship, Drug, Azirines, Triazines, Aziridines, Drug Evaluation, Preclinical, Antineoplastic Agents, Neoplasms, Experimental, Rats, Lethal Dose 50, Mice, Sarcoma 37, Animals, Sarcoma, Experimental, Carcinoma, Ehrlich Tumor

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