In experiments on mice (put in triads and tetrads) stable domination-subordination relations (DS) of predominantly despotic type were formed. The experiments were staged in specially designed communicating populational cages. Pharmacological evidence of inertness of DS relations in small groups of mice is presented. Critical factors of DS inertness are examined. It is shown that psychotropic drugs of different classes have difficult effect on the maintainance of DS inertness. Prolonged administration of psychotropic drugs suppressing the dominant's aggression may result in DS inversion.