Two cases of hereditary Morning Glory Syndrome (MGS) with serious damage to the second eye are described. Besides MGS there is simultaneous shrinking of both kidneys, and chronic glomerulonephritis is suspected. A further member of the family suffers from a pseudoneuritis nervi optici, but not from kidney disease. Our findings are compared with cases of MGS which have already been described. The particular symptoms of MGS are compared with known anomalies. After analyzing the literature and our cases the following can be said of MGS: Refraction and sight can be normal. The size of the optic disk varies between too large and too small. Regarding the morphology, the prominent elevated annulus around the optic disk is possibly identical with that in the case of pseudoneuritis. The MGS can be hereditary, and there may be simultaneous, chronic and progressive kidney disease. The course of the kidney disease can have serious consequences for the patient.