[Study of human secretory immunoglobulin A. I. Obtaining monospecific antiserum to human secretory immunoglobulin A].

G P, German; E V, Chernokhvostova; S Ia, Gol'derman

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Journal of microbiology epidemiology immunobiology

Article . 1976

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[Study of human secretory immunoglobulin A. I. Obtaining monospecific antiserum to human secretory immunoglobulin A].

descriptionPublicationkeyboard_double_arrow_right Article 30 Mar 1976 Russian Journal:Zhurnal mikrobiologii, epidemiologii i immunobiologii (issn: 0372-9311,

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Authors: G P, German; E V, Chernokhvostova; S Ia, Gol'derman;

pmid: 55017

[Study of human secretory immunoglobulin A. I. Obtaining monospecific antiserum to human secretory immunoglobulin A].

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Abstract

A method of obtaining monospecific antiserum to the human secretory IgA is described. Immunochemically pure secretory IgA (isolated from human colostrum by fractionation with ammonium sulfate and gel-filtration on Sephadex G-200) was used for immunization of rabbits or sheep. Heterologous antibodies were removed by adsorption with commercial gamma globulin, normal serum, the serum of a patient suffering from A-myeloma with the IgA polymere and purified lactoferrin. Monospecific antiserum to the secretory IgA gave a reaction of complete immunological identity with the secretory IgA and a free secretory component.

Keywords

Sheep, Colostrum, Immune Sera, Antibodies, Heterophile, Moscow, Immunoglobulin A, Epitopes, Lactoferrin, Immunoglobulin A, Secretory, Immunologic Techniques, Animals, Humans, Female, Immunization, Adsorption, Rabbits, Antigens, Immunoelectrophoresis

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