The American skin and mucous membrane leishmaniasis or mucocutaneous leishmaniasis is induced through phlebotomus bites and occurs in South and Central America. Untreated severe multilating ulcerations of the face with involvement of oral, nasal, and pharyngeal mucous membranes may occur. Therapy consists of intramuscular administration of three- or pentavalent antimon preparations. In failure-patients amphotericin B is used instead.