alpha-Amanitin resistant RNA polymerase II from Aedes albopictus cell mutants resistant to alpha-amanitin.
Copyright policy )alpha-Amanitin resistant RNA polymerase II from Aedes albopictus cell mutants resistant to alpha-amanitin.
Spontaneous and EMS-induced alpha-amanitin-resistant Aedes albopictus cells have been isolated and characterized. Two mutant sublines, one of intermediate resistance (alpha A2) and the other highly resistant (Ama18) contained RNA polymerase II activity, the resistance of which in vitro to alpha-amanitin correlated well with the resistance of these cells in vivo. The resistance of these cells to alpha-amanitin can likely be attributed to the presence of an altered RNA polymerase II.
Amanitins, Drug Resistance, DNA-Directed RNA Polymerases, Cell Line, Clone Cells, Phenotype, Aedes, Ethyl Methanesulfonate, Mutation, Animals, RNA Polymerase II
Amanitins, Drug Resistance, DNA-Directed RNA Polymerases, Cell Line, Clone Cells, Phenotype, Aedes, Ethyl Methanesulfonate, Mutation, Animals, RNA Polymerase II
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