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A review of the immunology of parasitic nematodes.

Authors: Valdivieso, Darío; Tamsitt, J. R.;

A review of the immunology of parasitic nematodes.

Abstract

 Se revisa la inmunología de infecciones causadas por nemátodos. La mayoría de las investigaciones realizadas hasta el presente han tratado con los mecanismos inmunológicos que resultan en la inhibición del desarrollo y en la pérdida subsecuente de parásitos adultos asociados con la administración de larvas infecciosas en un huésped resistente, p. ej ., el efecto de la inmunidad adquirida sobre la migración, desarrollo y establecimiento de la infección de desafío. Los mecanismos por medio de los cuáles la inmunidad del huésped afecta a los parásitos, sin embargo, son aún casi desconocidos; pero la evidencia actual indica que estos mecanismos dependen de factores humorales con una cooperación celular secundaria. Se revisan la inmunidad adquirida, los productos metabólicos usados como antígenos funcionales, el fenómeno de self-cure y la inmunidad artificial, lo mismo que las tendencias actuales de investigación. Se destaca la gran necesidad de estudios que produzcan información básica sobre el mecanismo de inmunidad contra nemátodos.

The immunology of nematode infections is reviewed. Most of the research has dealt with the immune responses which result in the inhibition of development and subsequent loss of adult infections associated with the administration of infective larvae to a resistant host, i. e., the effect of acquired immunity on the migration, development and establishment of the challange infection. The mechanisms by which the immunity of the host affects the parasites, however, is still not clear, but present evidence indicates that these mechanisms depend on humoral factors, with a secondary cellular cooperation. Acquired immunity, metabolic products as functional antigens, the "self-cure" phenomenon, and artificial immunity are discussed, and current research trends are reviewed. The need for studies yielding basic information on the mecha­ nism of nematode immunity is emphasized.

Keywords

Immunity, Cellular, Nematoda, Immunity, Active, Hypersensitivity, Animals, Humans, Immunization, Antigens, Nematode Infections, Anaphylaxis, Immunity, Maternally-Acquired, Forecasting

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citations
The total number of citations received by all articles of the researcher of interest.
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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