Clinical evaluation of Rho(D) immune globulin (human) in Canada.

E C, Bryant; G D, Hart; D, Cairns; J A, Gamarra; L L, de Veber; C G, Holland; J L, Hutchison

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Article . 1970

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Clinical evaluation of Rho(D) immune globulin (human) in Canada.

descriptionPublicationkeyboard_double_arrow_right Article 14 Feb 1970 English Journal:Canadian Medical Association journal, volume 101 (issn: 0008-4409,

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Authors: E C, Bryant; G D, Hart; D, Cairns; J A, Gamarra; L L, de Veber; C G, Holland; J L, Hutchison;

pmid: 4188450

pmc: PMC1946435

Clinical evaluation of Rho(D) immune globulin (human) in Canada.

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Abstract

-During 1966, clinical trials were conducted in three Canadian centres to determine the safety and efficacy of Rh(0)(D) immune globulin (human) in preventing isoimmunization by the Rh(0)(D) antigen in Rh-negative women delivering ABO-compatible Rh-positive infants.The candidates were randomly divided into control and treated groups; the treated mothers received an intramuscular injection of 300 mug. of anti-Rh(0)(D) within 72 hours of delivery. Follow-up antibody screening tests were conducted on the sera of all patients six to nine months post partum.Of the 175 control patients, 11 or 6.2% became actively immunized to the Rh antigen, whereas complete protection against maternal Rh immunization was observed in the 191 treated patients.

Keywords

Rh-Hr Blood-Group System, Delivery, Obstetric, Antibodies, ABO Blood-Group System, Erythroblastosis, Fetal, Pregnancy, Humans, Female, Immunization, gamma-Globulins, Follow-Up Studies

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