Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].

M A, Chirigos; E, Schlick; R, Ruffmann; W, Budzynski; P, Sinibaldi; E, Gruys

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Article . 1986

Data sources: Europe PubMed Central

Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].

descriptionPublicationkeyboard_double_arrow_right Article 24 Mar 1986 English Journal:Journal of biological response modifiers, volume 4 (issn: 0732-6580,

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Authors: M A, Chirigos; E, Schlick; R, Ruffmann; W, Budzynski; P, Sinibaldi; E, Gruys;

pmid: 4087033

Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].

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Abstract

Polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC] significantly augmented natural killer (NK) cell activity in several tissues. Macrophage (M phi) tumoricidal activity was also markedly increased. Both effector cells were active for 9 days. Poly(I,C)-LC also increased effector cell response in vitro. Injections of poly(I,C)-LC resulted in elevated effector cell responses in four of five routes tested. Treatment with poly(I,C)-LC led to an earlier reconstitution of bone marrow cells, NK cell activity, and M phi effector cell activity in mice pretreated with cyclophosphamide (Cytoxan). Combined treatment of MBL-2 tumor cells with cytoreductive chemotherapy and poly(I,C)-LC resulted in an enhanced therapeutic response.

Keywords

Leukemia, Experimental, Macrophages, Antineoplastic Agents, In Vitro Techniques, Methylcellulose, Killer Cells, Natural, Kinetics, Mice, Poly I-C, Carboxymethylcellulose Sodium, Animals, Drug Therapy, Combination, Female, Polylysine, Cyclophosphamide

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