[Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
Copyright policy )[Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
It is shown that the administration of ethanol to male Wistar rats (3 g/kg by gastric tube 3 times a week for 2 months) before or at the beginning of the N-nitrosodiethylamine (NDEA) treatment (2.5 mg/kg 6 times a week in drinking water) reduces the hepatocarcinogenicity of NDEA. This was expressed macroscopically by less important neoplastic changes and biochemically by the higher glucose-6-phosphatase and lower glucose-6-phosphate dehydrogenase activities in the liver.
Male, Liver Neoplasms, Experimental, Time Factors, Ethanol, Liver, Histocytochemistry, Animals, Diethylnitrosamine, Drug Interactions, Rats, Inbred Strains, Rats
Male, Liver Neoplasms, Experimental, Time Factors, Ethanol, Liver, Histocytochemistry, Animals, Diethylnitrosamine, Drug Interactions, Rats, Inbred Strains, Rats
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