The hemolytic activity of citral--II. Glutathione depletion in citral treated erythrocytes.

R, Segal; I, Milo-Goldzweig

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Biochemical Pharmaco...arrow_drop_down

Biochemical Pharmacology

Article . 1985

Data sources: Europe PubMed Central

The hemolytic activity of citral--II. Glutathione depletion in citral treated erythrocytes.

descriptionPublicationkeyboard_double_arrow_right Article 18 Dec 1985 English Journal:Biochemical pharmacology, volume 34 (issn: 0006-2952,

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Authors: R, Segal; I, Milo-Goldzweig;

pmid: 4062979

The hemolytic activity of citral--II. Glutathione depletion in citral treated erythrocytes.

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Abstract

The role of glutathione in citral induced hemolysis was investigated. The concentration of intracellular glutathione diminished in citral treated erythrocytes. GSH disappeared before hemolysis started. Glucose inhibited citral induced hemolysis and restored the depleted cellular stores of GSH. The results presented confirm the previous suggestion that a free radical-peroxide mechanism is involved in citral induced hemolysis.

Keywords

Erythrocytes, Free Radicals, Terpenes, Acyclic Monoterpenes, Monoterpenes, Humans, Glutathione, Hemolysis

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