Accurate emission inventories are essential for effective ozone pollution control in urban areas. Cangzhou has been frequently plagued by volatile organic compounds （VOCs） pollution along with its rapid economic development and urbanization in recent years. In this study， a high spatial resolution VOCs emission inventory for Cangzhou was established for the year 2021 using source-specific emission factors and the latest activity data from different sources. The anthropogenic sources considered in this study were classified into seven major sources and 29 subcategories. The results indicated that a total of 69.7 kt of anthropogenic VOCs were emitted in Cangzhou in 2021. The industrial process source was identified as the largest emission source category， accounting for 66.8% of the total emissions. The main components of Cangzhou VOCs were alkanes， aromatics， and oxygenated volatile organic compounds （OVOCs）. Alkanes were mainly from the oil， coal， and other fuel processing industries. Aromatics were mainly from the ferrous metal smelting and rolling processing industry. OVOCs were mainly from the rubber and plastic products industry. The total OFP of anthropogenic VOCs in Cangzhou was 207.4 kt， with the aromatics and industrial processes source being the major contributing components and emission source category. The top 10 species contributing to OFP emissions in Cangzhou were m/p-xylene； toluene； propylene； ethylene； o-xylene； 1-butene； ethylbenzene； pentane； 1，2，4-trimethylbenzene； and methyl ethyl ketone. Spatially， the Bohai New Area and Renqiu City were the top two emitters of VOCs. High VOCs emission regions were concentrated in industrial parks within various districts and counties. The anthropogenic VOCs component inventory constructed in this study provided critical data support for ozone pollution control and refined policy measures in Cangzhou.