The abdomen is a fixed space that functions at a normal physiologic pressure. Abdominal compartment syndrome (ACS) can arise from elevations in intra-abdominal pressure (IAP). Rising IAP has direct effects on the organs both within and outside the abdomen. These effects can be targeted using ultrasound for noninvasive and rapid diagnosis and management of ACS. ACS is a severe disease and the ability to rapidly diagnose and manage it with point of care ultrasound can significantly impact patient outcomes.