Psychiatric disorders are associated with a high prevalence of cardiovascular and metabolic risk factors such as diabetes, obesity, and metabolic syndrome, as well as specific symptoms: hyperphagia, weight gain, hypersomnia, fatigue, and anhedonia. Non-pharmacological therapeutic strategies (exercise, Mediterranean or ketogenic diets) as well as pharmacological approaches, such as repositioning molecules (metformin or GLP1 receptor agonists), are available and could be proposed to these patients. In addition, targeting immuno-inflammatory pathways may be beneficial for these individuals.